CHIRAL CHEMICALS - An Exclusive Market Insight Report Update

It is important for a chiral drug to be present in a pure therapeutically active form so as to avoid the possibility of any untoward effects.

Hyderabad, India (prHWY.com) May 7, 2012 - April 18, 2012 - RI Technologies' ( http://www.researchimpact.com/ ) report on Chiral Chemicals focuses on the different methods and applications of Chiral Chemicals and their impact. Various Chiral Chemical preparation and separation methods include Traditional, Asymmetric, Biological and Other. Pharmaceuticals, Agrochemicals, Flavors/Fragrances are the different chiral chemical applications discussed. The study provides global market analysis for preparation of Chiral Chemicals by Traditional (Diastereomeric Crystallisation, Chromatography & Chiral Pool), Asymmetric (Synthesis & Catalysis) and Biological (Bio-catalysis & Kinetic Resolution). The study includes estimations and predictions for the total global Chiral Chemicals market. Market value for geographic regions including North America, Europe, Asia-Pacific, Japan, and Rest of World is also provided. The industry is analyzed in US Dollars and includes 225 exclusive exhibits. More than 350 companies are covered that are engaged in Chiral Chemical R&D, discovery, testing, and supply of products and services.

Chiral technology has made tremendous progress so much so that it can now be developed with ease. This has been made easier with the increase in chiral analytical techniques that are capable of differentiating between enantiomers either during development of the drug or while monitoring its results in the body. Despite the fact that chiral drugs have been in use much before the arrival of modern medicine, it is only now that chiral drugs in the pharmaceutical industry has gained so much attention. This is largely due to the understanding that enantiomers often show different bioactivity and metabolic fates. In addition there is also a commercial reason where pharmaceutical companies have the chance to extend patent coverage after expiry of patents on racemic drugs. This can take place through the development of the chiral switch enantiomers with suitable bioactivity.

The usual protocol on drug design and development involves making the isomer mixtures first after which the preferred isomer is selected. Recently there have been many developments in medicinal chemistry that makes use of automated rapid synthesis. This is based on connecting building blocks in a particular manner and this is combined with automated bioscreening for therapeutic activity and selectivity determination. Information gathered must be exact to validate the use of single isomers.

Today, synthetic and chiral drugs are commercially available. However, many of these chiral drugs are racemic mixtures. It is important for a chiral drug to be present in a pure therapeutically active form so as to avoid the possibility of any untoward effects. Therefore there is an urgency to develop a suitable technology for the analysis and separation of racemic drugs. The most important use of chiral technology is in its application in chiral drugs. Usually the most therapeutically effective form of a drug is the single enantiomer.

Chiral technology now plays an important role in normal drug design by helping in not just the formation but also the discovery of new receptor-based as well as enzyme-inhibiting small molecule drugs. This is seen especially in drugs that require high selectivity of action. The availability of many new technologies in abundance instead of single-enantiomer chiral drugs makes this technology more acceptable.


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Tag Words: chiral chemicals

Categories: Biotech

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