Use of Amlodipine alone provides a better effect than its combination

Amlodipine is a widely used medication to keep your blood pressure levels within normal limits and various studies have proven that it is the best anti-hypertensive medication due to its safety and accuracy.

Fontana, CA (prHWY.com) May 31, 2012 - May 31, 2012 USA (Realpharmacyrx.us): A recent survey claimed that Amlodipine when used in conjugation with aliskiren, an anti-hypertensive medicine was found to show the same effect as that of Amlodipine alone. The use of this combination medicine, which was approved by FDA in April 2011has been recently proved to have no added effect in lowering high blood pressure levels.

The current study focused on the conjunctive use of Amlodipine, one of the widely used anti-hypertensive medication and aliskiren in people suffering with essential hypertension and also in those hypertensive individuals in whom a single standard therapy was found not to be effective.
Amlodipine works as a calcium channel blocker that inhibits the uptake of calcium ions by the smooth muscle cells present in the arterial blood vessels. Hence, it causes dilation of the blood vessels thereby dropping the blood pressure and maintaining it within normal limits.
Whereas, aliskiren is found to lower your blood pressure by interfering with the production of hormones that are responsible for maintaining your blood pressure levels within the body and also obstructs the renin-angiotensin-aldosterone system.

The Federal Joint Committee (G-BA), at that time specified the use of this medicine combination as an effective and an appropriate therapeutic approach. Although the company which manufactured this combination medicine did show the deviation of the combined effect from the individual effect of both the medicine s, but it failed to give proper justifications to this deviation.
Also, the company failed to submit the relevant investigative studies shedding light on the fixed combination of the two medicine s (Amlodipine and aliskiren) and its link to the comparative therapy guidelines as lay down by the G-BA.

As a result, the additive effect of the medicine s and its effectiveness in relieving high blood pressure levels is still a question to be solved by the medicine manufacturer. Practically there exists no added beneficial effect of the medicine combination as per the review presented in the dossier of the manufacturer.
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Tag Words: healthcare, blood pressure

Categories: Health

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