Salvinorin A - Proven potentially to be New Lead Compound for Pain Medication

Salvinorin A is a proven medication for pain' the newest researches on Salvia disclosed the facts behind the popularity of Salvia around the world as a medication of pain management.

New York, NY (prHWY.com) November 2, 2012 - Salvinorin A is a proven medication for pain' the newest researches on Salvia disclosed the facts behind the popularity of Salvia around the world as a medication of pain management.

The researches published in different website indicate that though the demand for prohibition of Salvia in different states is increasing, the demand for salvia is mounting at an incredible rate as it contains the potential compound for treatment in neurology.

A recent research by Kimberly M Lovell published in Udini.proquest.com expressed, "Kappa opioid (KOP) receptors are involved in the control of several abuse related effects of central nervous system stimulants. Salvinorin A, the natural product is the active component of the hallucinogenic mint plant Salvia divinorum and the first non-nitrogenous natural product having high affinity and efficacy at KOP receptors. Salvinorin A contains a furan ring, which in other furan containing natural products such as teucrin A and aflatoxin B1 has been identified to cause hepatotoxicity. In efforts to develop a more desirable pharmacological tool, structural modifications were made to salvinorin A in efforts explore the role of the furan ring in affinity and activity at KOP receptors and to reduce its potential for hepatotoxicity."

Al Grand, a well known and often controversial herbalist said, "Salvinorin A is the first known naturally-occurring non-nitrogenous full kappa-opioid receptor agonist, and it is the only diterpenoid compound known to have activity at this important receptor. This has recently opened up vast new areas for research in diterpenoid pharmacology and it represents a potential molecular target for the development of herbs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder."


"Researchers, herbalists, mental health specialists, and especially addicts are showing interest in a Mexican sacramental herb that contains an anti-addictive pain killer that can even get people off other addicting substances. Salvia Divinorum references show how the herb can address alcohol, cocaine, opiate heroin and morphine, nicotine, tobacco and amphetamine addiction" He added.


Another Research done by a group of herbalists published in Molecular Pain.com reveals, "Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode of action of SA on formalin-induced persistent pain in mice. Specifically, the SA effects on long-term behavioural dysfuctions and changes in neuronal activity occurring at spinal level, after single peripheral formalin injection, have been investigated. Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated." In the world nothing is thoroughly superior or dreadful, Salvarin A may not out of any controversy at all. But its affirmative quality shadows the negative one, and contributes a lot in the world of neuro medicine.

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